The events shown in this arc happen off-screen in the manga, but the anime adds an extra bit of intrigue to this story. This arc centers around Orochimaru and the Akatsuki pursuing the three-tailed beast Isobu. The first major filler arc worth watching comes with episodes 91-111. These can expand upon major story beats or fill in some of the gaps from the manga. There are some filler episodes that are worth watching even though they don’t necessarily affect major storylines. Naruto Shippuden guide to good filler episodes

Some of the filler episodes are still worth a look. Though these episodes are filler, there are certain instances where they’re referenced in future non-filler episodes, but little is lost by skipping these episodes. There are entire seasons of filler, making it easy to just skip forward in the episode list and roll from there. The good news when it comes to Naruto Shippuden is that most of the extraneous episodes come in chunks.